|
KMID : 1129720130300010056
|
|
Korean Journal of Acupuncture
2013 Volume.30 No. 1 p.56 ~ p.63
|
|
|
Repetitive Electroacupuncture Alleviate Neuropathic Pain in Association with Suppressing Activation of Spinal Glial Cells
|
|
이흔주:Lee Heun-Joo
정보은:Jeong Bo-Eun/송다은:Song Da-Eun/구성태:Koo Sung-Tae/박민영:Park Min-Young
|
|
|
Abstract
|
|
|
Objectives : Effects of repetitive electroacupuncture(EA) on the pain behavior and activation of spinal glial cells were examined in the rat model of neuropathic pain.
Methods : Twenty one adult male Sprague-Dawley rats were randomly assigned into 3 groups(control group, SP6 group, ST36+GB34 group). Neuropathic pain was induced by tight ligation of L5 spinal nerve. Mechanical and thermal hypersensitivity of hind paw were tested. Immunohistochemistry was performed in spinal cord L5/6 of all groups. EA was treated once in a day from the 5th day after surgery.
Results : EA treatments applied to ST36 and GB34 reduced significantly both of mechanical and thermal hypersensitivity after 3 times of treatment throughout the experiments. In the SP6 group, the analgesic effect was also shown after 7 times of treatment. Immunohistochemistry demonstrated inhibition of microglia and astrocyte activation in the spinal cord L5/6 dorsal horn in the ST36+GB34 group.
Conclusions : The present results suggest that repetitive EA exert strong analgesic effect on neuropathic pain. These analgesic effects in neuropathic pain are associated with suppressing the activation of microglia and astrocyte.
|
|
|
KEYWORD
|
|
|
neuropathic pain, electroacupuncture, spinal nerve ligation, glial activation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|